Measured Creatinine Clearance (Timed Urine CCr)
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Enter the total collected urine over the ACTUAL collection duration, not a 24-hour extrapolation. Verify collection completeness and timing of serum sampling. Collections other than 24 hours require protocol review. No normality assessment is inferred.
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Formula, collection requirements, and sources
Arithmetic and units
Unadjusted CCr (mL/min) = urine creatinine (mg/dL) / serum creatinine (mg/dL) × total urine volume (mL) / [actual collection duration (hours) × 60]. BSA (m²) = 0.007184 × height (cm)^0.725 × weight (kg)^0.425 (Du Bois). Indexed CCr (mL/min/1.73 m²) = raw CCr × 1.73/BSA. Results use different units.
Hypothetical example
At 170 cm and 65 kg, urine creatinine 100 mg/dL, serum creatinine 1.0 mg/dL, total volume 1440 mL and 24 hours: raw CCr 100.0 mL/min, BSA about 1.754 m² and indexed CCr about 98.7 mL/min/1.73 m².
Applicability and limitations
Collection completeness and simultaneous serum sampling are important. Tubular creatinine secretion can cause CCr to overestimate GFR. This is not an eGFR conversion, normal/abnormal classification, or medication dose recommendation. The total collected urine volume must correspond to the entered time.
Review and evidence
Sources verified 2026-11-10.