Adult Kidney Function: CCr and eGFR
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Original equations use these two coefficients; other situations require individual professional assessment.
Creatinine-based estimates may be unreliable in acute kidney injury, rapid changes in Cr, unusual muscle mass, pregnancy, edema, or inappropriate weight selection. No drug dosage guidance is provided.
Historical equations (comparison only)
Verify the serum Cr assay and calibration.
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Equations, assay compatibility and population
Primary equations
JSN 2009 standardized eGFR = 194 × Cr^−1.094 × age^−0.287 (female multiplier 0.739), mL/min/1.73 m², for Japanese adults. Cockcroft–Gault 1976 CCr = (140 − age) × selected weight(kg)/(72 × Cr mg/dL) (female multiplier 0.85), in nonindexed mL/min.
Historical equations
Japanese IDMS-MDRD 2009 = 0.808 × 175 × Cr^−1.154 × age^−0.203 (female multiplier 0.742), standardized Cr. Historical original MDRD 2000 = 186 × Cr^−1.154 × age^−0.203 (female multiplier 0.742), for old nonstandardized Jaffé measurement only. No race multiplier is applied in this page and the old formula is not recommended for clinical use in Japanese populations.
Assay gates and weight
Do not feed old Jaffé Cr directly into modern JSN formulas or standardized Cr into the historical original MDRD. This tool does not automatically add 0.2 mg/dL or convert between assay standards. Cockcroft–Gault is directly proportional to the chosen weight; individual actual/ideal/adjusted weight selection and unindexing eGFR require professional review and additional data. No clinical diagnosis or dose adjustment.
Hypothetical example
Male aged 60, 72 kg, standardized Cr 1 mg/dL: CCr 80.0 mL/min, JSN eGFR 59.9 mL/min/1.73 m², Japanese IDMS-MDRD 61.6 mL/min/1.73 m²; original MDRD is unavailable under standardized calibration.
Sources and approval
Source verification 2026-11-10.